| loco | (adjective) informal or slang terms for mentally irregular | Synonyms: around the bend, balmy, barmy, bats, batty, bonkers, buggy, cracked, crackers, daft, dotty, fruity, haywire, kookie, kooky, loony, loopy, nuts, nutty, round the bend, wacky, whacky |
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| locoism | (noun) a disease of livestock caused by locoweed poisoning; characterized by weakness and lack of coordination and trembling and partial paralysis | Synonyms: loco disease |
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| locomote | (verb) change location; move, travel, or proceed, also metaphorically | Synonyms: go, move, travel |
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| locomotion | (noun) self-propelled movement | Synonyms: travel |
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| (noun) the power or ability to move | Synonyms: motive power, motivity |
| locomotive | (adjective) of or relating to locomotion | Synonyms: locomotor |
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| (noun) a wheeled vehicle consisting of a self-propelled engine that is used to draw trains along railway tracks | Synonyms: engine, locomotive engine, railway locomotive |
| locomotor | (adjective) of or relating to locomotion | Synonyms: locomotive |
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| locoweed | (noun) street names for marijuana | Synonyms: dope, gage, grass, green goddess, Mary Jane, pot, sens, sess, skunk, smoke, weed |
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| (noun) any of several leguminous plants of western North America causing locoism in livestock | Synonyms: crazy weed, crazyweed |