| unsaddle | (verb) remove the saddle from | Synonyms: offsaddle |
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| unsanctify | (verb) remove the sanctification from or make unsanctified | - |
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| unsay | (verb) take back what one has said | Synonyms: swallow, take back, withdraw |
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| unscramble | (verb) make intelligible | - |
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| (verb) become or cause to become undone by separating the fibers or threads of | Synonyms: unknot, unpick, unravel, untangle |
| unscrew | (verb) loosen something by unscrewing it | - |
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| (verb) loosen by turning | - |
| unseal | (verb) break the seal of | - |
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| unseat | (verb) dislodge from one's seat, as from a horse | - |
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| (verb) remove from political office | - |
| unsee | (verb) to forget an image | - |
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| unsettle | (verb) disturb the composure of | Synonyms: enervate, faze, unnerve |
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| unsex | (verb) make infertile | Synonyms: desex, desexualise, desexualize, fix, sterilise, sterilize |
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| (verb) remove the qualities typical of one's sex | - |
| (verb) deprive of sex or sexual powers | - |
| unsheathe | (verb) draw from a sheath or scabbard | - |
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| unsnarl | (verb) extricate from entanglement | Synonyms: disentangle, straighten out |
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| unsolder | (verb) remove the soldering from | - |
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| unspell | (verb) release from a spell | - |
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| unstaple | (verb) take the staples off | - |
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| unstrain | (verb) cause to feel relaxed | Synonyms: loosen up, make relaxed, relax, unlax, unwind |
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| unstrap | (verb) remove the strap or straps from | - |
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| unstring | (verb) remove the strings from | - |
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| unstuff | (verb) cause to become unblocked | Synonyms: loosen up |
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| unsubstantialise | (verb) render immaterial or incorporeal | Synonyms: immaterialise, immaterialize, unsubstantialize |
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| unsubstantialize | (verb) render immaterial or incorporeal | Synonyms: immaterialise, immaterialize, unsubstantialise |
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