| backspace | (verb) hit the backspace key on a computer or typewriter keyboard | - |
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| bespangle | (verb) dot or sprinkle with sparkling or glittering objects | - |
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| (verb) decorate with spangles | Synonyms: spangle |
| bespatter | (verb) spot, splash, or soil | Synonyms: spatter |
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| despair | (verb) abandon hope; give up hope; lose heart | - |
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| despatch | (verb) send away towards a designated goal | Synonyms: dispatch, send off |
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| disparage | (verb) express a negative opinion of | Synonyms: belittle, pick at |
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| dispatch | (verb) kill without delay | - |
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| (verb) send away towards a designated goal | Synonyms: despatch, send off |
| (verb) complete or carry out | Synonyms: complete, discharge |
| (verb) kill intentionally and with premeditation | Synonyms: bump off, hit, murder, off, polish off, remove, slay |
| (verb) dispose of rapidly and without delay and efficiently | - |
| inspan | (verb) attach a yoke or harness to | - |
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| outspan | (verb) remove the yoke or harness from | - |
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| space | (verb) place at intervals | - |
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| spacewalk | (verb) move in space outside a space craft | - |
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| spade | (verb) dig (up) with a spade | - |
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| spam | (verb) send unwanted or junk e-mail | - |
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| span | (verb) to cover or extend over an area or time period | Synonyms: cross, sweep, traverse |
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| spang | (verb) leap, jerk, bang | Synonyms: bang |
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| spangle | (verb) decorate with spangles | Synonyms: bespangle |
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| (verb) glitter as if covered with spangles | - |
| spank | (verb) give a spanking to; subject to a spanking | Synonyms: larrup, paddle |
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| spar | (verb) fight verbally | - |
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| (verb) box lightly | - |
| (verb) fight with spurs | - |
| (verb) furnish with spars | - |
| spare | (verb) use frugally or carefully | - |
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| (verb) give up what is not strictly needed | Synonyms: dispense with, give up, part with |
| (verb) refrain from harming | Synonyms: save |
| (verb) save or relieve from an experience or action | - |
| sparge | (verb) scatter with liquid; wet lightly | Synonyms: besprinkle, sprinkle |
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| (verb) agitate by introducing air or compressed gas | - |
| spark | (verb) put in motion or move to act | Synonyms: activate, actuate, set off, spark off, touch off, trigger, trigger off, trip |
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| (verb) emit or produce sparks | Synonyms: sparkle |
| sparkle | (verb) become bubbly or frothy or foaming | Synonyms: effervesce, fizz, foam, form bubbles, froth |
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| (verb) be lively or brilliant or exhibit virtuosity | Synonyms: coruscate, scintillate |
| (verb) reflect brightly | Synonyms: coruscate, scintillate |
| (verb) emit or produce sparks | Synonyms: spark |
| spat | (verb) clap one's hands together | Synonyms: clap |
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| (verb) spawn | - |
| (verb) engage in a brief and petty quarrel | - |
| (verb) clap one's hands or shout after performances to indicate approval | Synonyms: acclaim, applaud, clap |
| (verb) strike with a sound like that of falling rain | - |
| (verb) become permanently attached | - |
| (verb) come down like raindrops | - |
| spatchcock | (verb) interpolate or insert (words) into a sentence or story | - |
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| (verb) prepare for eating if or as if a spatchcock | - |
| spatter | (verb) dash a liquid upon or against | Synonyms: plash, splash, splatter, splosh, swash |
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| (verb) spot, splash, or soil | Synonyms: bespatter |
| (verb) rain gently | Synonyms: patter, pitter-patter, spit, sprinkle |
| spawn | (verb) lay spawn | - |
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| (verb) call forth | Synonyms: breed, engender |
| spay | (verb) remove the ovaries of | Synonyms: alter, castrate, neuter |
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| spaz | (verb) to act insanely | - |
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| trespass | (verb) pass beyond (limits or boundaries) | Synonyms: overstep, transgress |
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| (verb) break the law | - |
| (verb) enter unlawfully on someone's property | Synonyms: intrude |
| (verb) commit a sin; violate a law of God or a moral law | Synonyms: sin, transgress |
| (verb) make excessive use of | Synonyms: take advantage |