| isolation | (noun) the act of isolating something; setting something apart from others | Synonyms: closing off |
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| (noun) a country's withdrawal from international politics | - |
| (noun) a feeling of being disliked and alone | - |
| (noun) (psychiatry) a defense mechanism in which memory of an unacceptable act or impulse is separated from the emotion originally associated with it | - |
| (noun) a state of separation between persons or groups | - |
| isolationism | (noun) a policy of nonparticipation in international economic and political relations | - |
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| isolationist | (noun) an advocate of isolationism in international affairs | - |
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| isoleucine | (noun) an essential amino acid found in proteins; isomeric with leucine | - |
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| isolex | (noun) an isogloss marking off the area in which a particular item of vocabulary is found. | - |
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