| sighted | (adjective) able to see | - |
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| sightless | (adjective) lacking sight | Synonyms: eyeless, unseeing |
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| sightly | (adjective) very pleasing to the eye | Synonyms: bonnie, bonny, comely, fair |
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| sigmoid | (adjective) of or relating to the sigmoid flexure in the large intestine | Synonyms: sigmoidal |
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| (adjective) curved in two directions (like the letter S) | - |
| sigmoidal | (adjective) of or relating to the sigmoid flexure in the large intestine | Synonyms: sigmoid |
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| sign | (adjective) used of the language of the deaf | Synonyms: gestural, sign-language, signed |
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| signal | (adjective) notably out of the ordinary | - |
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| signed | (adjective) having a handwritten signature | - |
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| (adjective) used of the language of the deaf | Synonyms: gestural, sign-language, sign |
| significant | (adjective) important in effect or meaning | Synonyms: important |
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| (adjective) too closely correlated to be attributed to chance and therefore indicating a systematic relation | - |
| (adjective) of considerable importance, size, or worth | Synonyms: substantial |
| (adjective) rich in significance or implication | Synonyms: meaning, pregnant |
| significative | (adjective) (usually followed by `of') pointing out or revealing clearly | Synonyms: indicative, indicatory, revelatory, suggestive |
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