| upscale | (adjective) appropriate for people with good incomes | - |
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| upset | (adjective) thrown into a state of disarray or confusion | Synonyms: broken, confused, disordered |
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| (adjective) mildly physically distressed | - |
| (adjective) afflicted with or marked by anxious uneasiness or trouble or grief | Synonyms: disquieted, distressed, disturbed, worried |
| (adjective) having been turned so that the bottom is no longer the bottom | Synonyms: overturned, upturned |
| (adjective) used of an unexpected defeat of a team favored to win | - |
| upsetting | (adjective) causing an emotional disturbance | Synonyms: disconcerting |
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| upstage | (adjective) of the back half of a stage | - |
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| (adjective) remote in manner | Synonyms: aloof, distant |
| upstair | (adjective) on or of upper floors of a building | Synonyms: upstairs |
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| upstairs | (adjective) on or of upper floors of a building | Synonyms: upstair |
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| upstanding | (adjective) meriting respect or esteem | Synonyms: solid |
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| upstart | (adjective) characteristic of someone who has risen economically or socially but lacks the social skills appropriate for this new position | Synonyms: nouveau-riche, parvenu, parvenue |
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| upstream | (adjective) in the direction against a stream's current | - |
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